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Related Publications and Patents

Yang, M., Li, L., Jiang, P., Moossa, A.R., Penman, S., and Hoffman, R.M.  Dual-color fluorescence imaging distinguishes tumor cells from induced host angiogenic vessels and stromal cells.  Proc. Natl. Acad. Sci. USA 100, 14259-14262, 2003.
Yang, M., Reynoso, J., Jiang, P., Li, L., Moossa, A.R., and Hoffman, R.M.  Transgenic nude mouse with ubiquitous green fluorescent protein expression as a host for human tumors.  Cancer Research 64, 8651-8656, 2004.
Hoffman, R.M., and Yang, M.  Color-coded fluorescence imaging of tumor-host interactions.  Nature Protocols 1, 928-935, 2006.
Bouvet, M., Tsuji, K., Yang, M., Jiang, P., Moossa, A.R., and Hoffman, R.M.  In vivo color-coded imaging of the interaction of colon cancer cells and splenocytes in the formation of liver metastases.  Cancer Research 66, 11293-11297, 2006.
Yang, M., Jiang, P., and Hoffman, R.M.  Whole-body subcellular multicolor imaging of tumor-host interaction and drug response in real time.  Cancer Res. 67, 5195-5199, 2007.
Yang, M., Reynoso, J., Bouvet, M., and Hoffman, R.M.  A transgenic red fluorescent protein-expressing nude mouse for color-coded imaging of the tumor microenvironment.  J. Cell. Biochem. 106, 279-284, 2009.
Tran Cao, H.S., Reynoso, J., Yang M., Kimura, H., Kaushal, S., Snyder, C.S., Hoffman, R.M., and Bouvet M.  Development of the transgenic cyan fluorescent protein (CFP)-expressing nude mouse for “Technicolor” cancer imaging.  J. Cell. Biochem 107, 328-334, 2009.
Suetsugu, A., Hassanein, M.K., Reynoso, J., Osawa, Y., Nagaki, M., Moriwaki, H., Saji, S., Bouvet, M., and Hoffman, R.M.  The cyan fluorescent protein nude mouse as a host for multicolor-coded imaging models of primary and metastatic tumor microenvironments.  Anticancer Res. 32, 31-38, 2012.
Suetsugu, A., Katz, M., Fleming, J., Truty, M., Thomas, R., Moriwaki, H., Bouvet, M., Saji, S., and Hoffman, R.M.  Multi-color palette of fluorescent proteins for imaging the tumor microenvironment of orthotopic tumorgraft mouse models of clinical pancreatic cancer specimens.  J. Cell. Biochem. 113, 2290-2295, 2012.
Hiroshima, Y., Maawy, A., Hassanein, M.K., Menen, R., Momiyama, M., Murakami, T., Miwa, S., Yamamoto, M., Uehara, F., Yano, S., Mori, R., Matsuyama, R., Chishima, T., Tanaka, K., Ichikawa, Y., Bouvet, M., Endo, I., and Hoffman, R.M..  The tumor-educated-macrophage increase of malignancy of human pancreatic cancer is prevented by Zoledronic acid.  PLoS One 9(8), e103382, 2014.
Yano, S., Hiroshima, Y., Maawy, A., Kishimoto, H., Suetsugu, A., Miwa, S., Toneri, M., Yamamoto, M., Katz, M.H.G., Fleming, J.B., Urata, Y., Tazawa, H., Kagawa, S., Bouvet, M., Fujiwara, T., and Hoffman, R.M.  Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery.  Cancer Gene Therapy 22, 344-350, 2015.
Hoffman, R.M. Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts. Nature Reviews Cancer V.15 8. 451- 452, 2015
Patents
Dual-color model Immunocompromised rodents as dual-color tumor models US  8,148,600
Dual-color model Immunocompromised rodents as dual-color tumor models Australia   2004212465
Dual-color model GFP and other fluorescent protein transgenic nude mice             Japan  4658809